The custom-made N5Air space sanitizing system creates a healthy indoor environment reducing the probability of an infection spread by destroying viruses and pathogens present in the air. Any home with a central HVAC qualifies. N5Air system addresses current health concerns related to the COVID-19 virus that is transmitted mainly through the respiratory pathway via air. The UVC sets of lamps are installed in the return air ducts. Their size and orientation are selected such that the air residence and exposure time to UVC light is maximized to enhance the effectiveness of the air sanitizing.